Endocrine Abstracts

Introduction: Radiofrecuency ablation (RFA) represents an alternative to surgery for benign thyroid nodules with pressure symptoms or evident progressive growth.Objetives: To analyze in our center the efficacy and safety at 6 montns of a single session treatment of RFA performed in predominantly solid thyroid nodules.Patients and methods: 17 patients with citologically benign thyroid nodules with pressure symptoms (dysphonia, dyspn...

Introduction: Guidelines suggest that serum basal (nonstimulated) thyroblobulin (bTg) with sensitive assays (Functional Sensitivity-FS- below 0.1 or 0.2 ng/ml) could substitute the measurement of serum Tg levels after TSH stimulation during the follow-up of patients with differentiated thyroid cancer (DTC) when basal results fall below the FS.Objective: A sensitive assay for Tg was incorporate in our center (Chemiluminiscent Tg Access; Beckam Coulter; Br...

Introduction: Hypercalcaemia secondary to malignancy is rare in childhood. Bisphosphonates have previously been shown to be effective in managing such cases in adults, however caution must be exercised in patients with renal failure or respiratory compromise. Denosumab, a RANKL monoclonal antibody is a very potent inhibitor of osteoclasts and can induce hypocalcaemia. It is not excreted by the kidney. Limited trials in adults have shown denosumab to have greater efficacy compa...

IntroductionThyrotropinoma is a rare pituitary tumor ( <2% of pituitary adenomas) arising from PIT1-lineage cells, which expresses and secrete TSH. In most cases, the etiology is unknown but rare cases have been described to arise in context of MEN 1 syndrome. Diagnosis is often delayed by confusion with primary hyperthyroidism, which determine the tumor to be already large and invasive at the time of diagnosis. GH and prolactin cosecretion is an increas...

Background: A pheochromocytoma is a rare neuroendocrine tumor, originating from adrenomedullary chromaffin cells. The pre-surgical management of pheochromocytoma is classically performed with alpha-blockers. However, in some cases other pharmacological approaches can be considered.Objective: The aim of the study is to describe the clinical course of patients with pheochromocytoma prepared for surgery with calcium channel blockers (CCB).<p class="abst...

Introduction: The use of iodinated contrast media (ICM) can lead to thyrotoxicosis, especially in patients with risk factors, such as Graves’ disease, multinodular goiter, older age, and iodine deficiency. Although hyperthyroidism may have clinically relevant effects, whether high-risk patients should receive prophylactic treatment before they are administered ICM is still debated.Aim of the study: We aimed to demonstrate the safety and efficacy of ...

Introduction: Morgagni–Stewart–Morel syndrome is defined as the absolute presence of hyperostosis frontalis interna, associated with metabolic, endocrine, and neuropsychiatric disorders. There are very few cases reported in the literature and some experts do not even recognize it but the exact etiology of the syndrome remains unclear; some theories relate to estrogen dysfunction, obesity and leptin dysfunction, and genetic alterations....

Objective: Transforming growth factor beta receptor 3 like (TGFBR3L) has been recently described as a pituitary-specific membrane protein detected in a proportion of the gonadotroph cells in non-neoplastic and tumour tissue (1). Furthermore, mouse studies have indicated that TGFBR3L is an inhibin B co-receptor that regulates FSH levels (2). We hypothesized that TGFBR3L expression in gonadotroph non-functioning pituitary neuroendocrine tumours (NF-PitNETs) is related to clinica...

Introduction: Primary hyperparathyroidism is a condition in which one or more parathyroid glands have a pathological secretion of parathyroid hormone due to their abnormal function. Secondary hyperparathyroidism has normal parathyroid glands, but an abnormal secretion of PTH because of an underlying condition that influence their activity. It is important to differentiate between primary and secondary hyperparathyroidism because of the different treatment.<p class="abstext...

Introduction: Osteocalcin is a bone-specific hormone also involved in regulation of glucose and fat mass metabolism. It regulates energy expenditure by acting on adipocytes and pancreatic islet cells. The aim of the present study was to examine the relation between serum osteocalcin and glucose metabolism in young women with obesity. Material and methods: A total of 66 healthy women were included in the analysis. Data on body mass index (BMI), waist circ...